About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 4000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

Requisition 10464

Job Title: Postdoctoral Fellowship | Cell Signalling and Epigenetic Mechanisms Mediating Circadian Clock Functions

Position Summary and Key Responsibilities:

Two Postdoctoral Fellow positions are immediately available in the laboratory of Dr. Ke Ma, Associate Professor, at the Diabetes and Metabolism Research Institute ( at City of Hope in Los Angeles. By applying state-of-the-art circadian biology to diabetes and obesity research, Ma lab has established a unique research niche to dissect the coordinated control of circadian clock circuit in metabolic tissue growth and functional capacity. The broad goal of our research is to better understand the temporal control in metabolic diseases to uncover circadian etiologies underlying the development of diabetes and cancer for targeted therapeutic interventions. We are looking for highly motivated postdoctoral fellows to study novel signaling and epigenetic mechanisms mediating circadian clock functions in adipose tissue and skeletal muscle. Our research utilizes biochemical and molecular biology approaches in genetic mouse models and circadian biology. Specific research directions in Ma Lab will explore, 1), epigenetic networks mediating clock nutrient-sensing function in adipose tissue and skeletal muscle, 2), circadian clock regulation of skeletal muscle growth, development and metabolism, and 3), novel roles of circadian regulators in cancer development and metabolism.

For a list of lab publications, please see:

Link for applying to these positions:

PI Webpage at the Diabetes and Metabolism Research Institute at City of Hope in LA:

The candidate should be self-motivated, with a proven track record of productivity and strong interest in metabolic disease research. Expertise in biochemistry, molecular biology and animal metabolic studies is preferred, and technical skill in stem cell research and epigenetics is a plus. To apply, please provide your CV and a list of three references.

Minimum Education and Skills Required for Consideration:

  • PhD in Molecular, Cellular or Developmental Biology.

  • Proficiency with biochemical techniques, molecular biology skills and cell culture systems.

  • Experience with in vivo animal model research preferred.

  • Experience with stem cell research preferred.

  • Experience with epigenetics research a plus.

  • Highly motivated and strong research interest in metabolic disease.

  • Strong work ethic and ability to work effectively in a team.

For additional information, please contact PI directly:

Ke Ma, MD, PhD

Associate Professor

Department of Diabetes Complications and Metabolism

Diabetes and Metabolism Research Institute

Beckman Research Institute, City of Hope

Duarte, CA, 91010

City of Hope is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color national origin, sex, age, status as a protected veteran, or status as a qualified individual with disability.

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Postdoctoral Fellowship | Cell Signalling And Epigenetic Mechanisms Mediating Circadian Clock Functions Located At CA, Duarte - Job Post By: City Of Hope

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