DUTIES AND RESPONSIBILITIESGuide and support the LNP formulation and process developmentSupport a core function of the team to produce, characterize, and optimize LNP formulationsEstablish and implement a toolset to support LNP process development. This will include high throughput screening technologies and mixing systemsDrive fundamental improvement of LNP synthesis understanding towards enhancements and simplification of LNP formationScreen novel lipids for improved in vivo potencySupport the generation of preclinical LNP material generationDrive the selection, tech transfer, and coordination of contract manufacturing organizations (CMOs) for GMPSupport the writing of protocols and technical reports to support drug product clinical developmentOrganize work flows as well as completing individual and team objectives to maintain project timelinesIn-depth track record of understanding and experience of RNA containing LNP synthesis and processingUnderstanding of lipid chemistry, lipid modifications, lipid synthesis, and standard analytical techniques for macromoleculesDemonstrated understanding of the current therapeutic discovery, and process development, especially in gene therapy, gene editing, mRNA, RNAi, or antisense Support the interactions across the company on behalf of the team to ensure alignment of the teams activity with company prioritiesWork with founders and executive team in building out companys research development plan and strategyWill be involved with developing core IP around early research workBASIC QUALIFICATIONSPhD (or MSc with work experience equivalent) with specialization in Biochemistry, Chemical Engineering, Biology, Molecular Biology or related scientific discipline.Previous team leadership experience. Ideally has led teams that submitted INDs.2+ years of industry experience in preclinical candidate development focused on genetic diseaseDirect industry experience in gene therapy or gene editing technologiesOutstanding teamwork, communication, and interpersonal skills.Team leadership experience with a demonstrated track record of personnel developmentPREFERRED QUALIFICATIONSExperience with mRNA, DNA, siRNAExperience with non-viral delivery methods (eg lipid nanoparticles). Ability to initiate and direct interactions and collaborations with KOLsJob Type: Full-timePay: $120,000.00 – $200,000.00 per yearBenefits:Dental InsuranceHealth insurancePaid time offSchedule:Monday to FridayEducation:Doctorate (Preferred)MSc w/ industry experienceExperience:Research Experience: 1 year (Preferred)Work Location: San Francisco (In person)
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Science
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